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评估随机对照试验的脆弱性指数,以支持术后护理指南:一个方法调查协议

Margarita Otalora-Esteban1,2, Martha Beatriz Delgado-Ramirez2,3, Fabian Gil2

  • 1Department of Anesthesiology and Pain Medicine, Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.

PloS one
|September 12, 2024
PubMed
概括

这项研究引入了脆弱性指数 (FI),以评估随机对照试验 (RCT) 在麻醉学临床实践指南中的稳定性. 它评估了需要改变多少患者结局来改变试验意义,以告知指南质量.

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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
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