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光自组合复合体基于糖基功能化G-四重复合体作为一个有针对性的交付平台

Xian Wang¹, Hui Ling Seah², Xiao-Lin Zhang¹

¹School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.

ACS applied materials & interfaces

|September 12, 2024

概括

我们开发了pH敏感的自组合复合体 (SACs),用于向药物输送. 这些复合物选择性地向癌细胞,减少副作用并增强精密医学的抗癌疗效.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
药物输送系统药物输送系统

背景情况:

精准医学需要先进的药物输送系统,以提高疗效和降低毒性.
刺激响应释放和有针对性的输送是理想治疗平台的关键特征.
开发具有简单准备和组合有效载荷能力的多功能平台至关重要.

研究的目的:

开发pH敏感的光自组合复合物 (SACs) 用于向药物输送.
创建一个能够共同提供治疗剂的多功能平台.
评估开发的SAC的目标交付,安全性和有效性.

主要方法:

纳米沉方法被用于合成银河糖功能化的G-四重复合物 (G4) 和氨酸碳胺衍生物SACs.
使用光成像来评估肝细胞癌 (HepG2) 细胞的选择性向.
与前药物floxuridine oligomers和SAC进行了同时递送的研究,以评估对正常 (NIH/3T3) 和癌细胞的细胞毒性.

主要成果:

开发的SAC证明了对HepG2细胞的选择性向.
与SACs同时提供floxuridine寡合体显著降低了对正常细胞的细胞毒性,同时保持了抗癌疗效.
该平台显示了有针对性的组合疗法的潜力,具有最小的溶血效应.

结论:

对pH敏感的光SACs作为精密医学的有效的有针对性的交付平台.
该策略使选择性向癌细胞和降低系统毒性成为可能.
这种自组装方法可以扩展到用于增强组合治疗的比度多药物输送.

关键词:

光成像成像技术的使用.光灯自组装复杂的复杂.银河糖功能化的G-四重复合体核酸原药是一种原药.有针对性的药物输送.

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