Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

764
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
764
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

655
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
655

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Resolution of chiral drug cocrystals: complementary roles of NMR, low-frequency Raman and vibrational circular dichroism.

Talanta·2026
Same author

Structural basis of Drosophila insulin receptor activation by DILP2 hormone.

Open biology·2026
Same author

An engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling.

Science advances·2026
Same author

Th@C<sub>84</sub> Revisited: Lost in the Corners of One's Own Cage.

The journal of physical chemistry. A·2026
Same author

Vesiculin reveals the role of the IGF2 C-domain in receptor specificity within the insulin-IGF system.

Protein science : a publication of the Protein Society·2026
Same author

Positive modulators of <i>N</i>-methyl-d-aspartate receptor: structure-activity relationship study on steroidal C-17 and C-20 oxime ethers.

RSC advances·2026

相关实验视频

Updated: Apr 30, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

24.3K

最后的步行与普雷普丁.

Lucie Mrázková1,2, Marta Lubos1, Jan Voldřich1

  • 1Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.

PloS one
|September 12, 2024
PubMed
概括

在新的研究中,来自pro-IGF2的质普列在新研究中没有显著的生物活性. 它的作用可能源于与IGF2的相互作用或实验条件,而不是独立的作用.

更多相关视频

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

11.9K
Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
08:36

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3

Published on: April 7, 2023

1.0K

相关实验视频

Last Updated: Apr 30, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

24.3K
Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

11.9K
Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
08:36

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3

Published on: April 7, 2023

1.0K

科学领域:

  • 内分泌学 在内分泌学.
  • 分子生物学分子生物学
  • 代谢研究研究 代谢研究

背景情况:

  • 普雷普丁是一种由亲胰岛素样生长因子2 (IGF2) 衍生的,与胰岛素分泌和骨代谢有关.
  • 普雷普丁的确切生理功能尚不清楚,需要进一步调查.

研究的目的:

  • 合成和评估前素类型的生物活性.
  • 为了澄清前素在生物系统中的生理作用.

主要方法:

  • 合成了16种普雷普丁类似物,包括全长形式和碎片形式.
  • 对不同细胞类型的原生人类,小鼠和老鼠前素相比,对类型的比较活性评估.

主要成果:

  • 对于普普丁或其合成的类似物,没有发现显著的生物活性.
  • 观察到的普普丁与疾病或组织丰富性的关联可能与IGF2水平或前型有关.

结论:

  • 普雷普丁似乎不作为一个孤立的,活跃的分子发挥作用.
  • 归因于普雷普丁的生物效应可能受到实验因素,度或与IGF2.2等分子的相互作用的影响.