重复性DNA元素的转录信号阻断了造血干细胞的细胞化

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Updated: Jun 13, 2025

Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
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Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation

Published on: October 20, 2014

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Cecilia Pessoa Rodrigues1,2, Joseph M Collins1,2, Song Yang1

  • 1Howard Hughes Medical Institute, Boston Children's Hospital Boston, MA, USA.

Science (New York, N.Y.)
|September 12, 2024
PubMed
概括

血造干细胞 (HSC) 的质量通过巨细胞的相互作用得到维持. 这项研究将Beta-2-微球蛋白 (B2m) 确定为"不要吃我"信号,揭示了HSC增殖和克隆性是如何调节的.

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