高效和低效的乳母在它们对牛早期胚胎压力的贡献上有所不同
Lindsey Fallon1, Kelsey N Lockhart2, Thomas E Spencer2
1Division of Animal Sciences, College of Agriculture, Food, and Natural Resources, University of Missouri, Columbia, MO, 65211, USA; and Present address: San Diego Zoo Wildlife Alliance, Escondido, CA 92027, USA.
Reproduction, fertility, and development
|September 12, 2024
概括
来自表现较低的母的胚胎显示出更高的氧化应激和自. 自可能有助于减轻压力,这表明 sire 选择可以改善胚胎发育.
科学领域:
- 生殖生物学 生殖生物学
- 胚胎学 胚胎学
- 细胞应激反应的细胞应激反应
背景情况:
- 雌雄的生育能力显著影响早期胚胎发育,影响胚胎细胞的活力.
- 在早期胚胎发育过程中,对 sire-mediated 细胞机制的理解有限.
- 氧化应激和自是关键的细胞过程,涉及到胚胎质量.
研究的目的:
- 在正常和压力条件下,从高和低表现的胎中对胚胎的自和活性氧物种 (ROS) 进行表征.
- 评估DNA损伤和脂质过氧化作为细胞应激反应的指标.
- 调查自在缓解胚胎发育早期的氧化应激过程中的作用.
主要方法:
- 胚胎来自四个高表现和四个低表现的母.
- 在整个胚胎发育过程中测量了自和ROS水平.
- 胚胎受到热应激以评估氧化应激反应,随后测量了自,ROS,DNA损伤和脂质过氧化.
主要成果:
- 在正常情况下,表现较低的母胚的胚胎表现出较高的ROS和自.
- 在热应激下,表现较低的母的胚胎显示ROS增加,而表现较高的母的胚胎显示自性增加.
- 两组之间没有观察到DNA损伤或脂质过氧化的显著差异.
结论:
- 来自表现较低的母体的胚胎可能会在较高的细胞压力下开始发育.
- 自似乎起到了补偿作用,有可能减轻这些胚胎的压力影响.
- 选择具有较低压力相关标记的母婴可以提高胚胎能力和发育潜力.
更多相关视频
14:40Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
Published on: October 25, 2015
9.4K
06:39Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
3.0K
相关概念视频
00:55Parental Care
Many animals exhibit parental care behavior, including feeding, grooming, and protecting young offspring. Parental care is universal in mammals and birds, which often have young that are born relatively helpless. Several species of insects and fish, as well as some amphibians, also care for their young.
01:12The Mammary Glands
The female breast is a hemispheric projection of variable size positioned anterior to the pectoralis major and serratus anterior muscles. A fascia layer composed of dense, irregular connective tissue connects it to these muscles.
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...