治疗自闭症谱系障碍的益生菌:对症状影响的更新系统审查和元分析
Saman Soleimanpour1, Mohammad Abavisani2, Alireza Khoshrou3
1Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Antimicrobial Resistance Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Journal of psychiatric research
|September 12, 2024
概括
益生菌补充剂显著改善了自闭症谱系障碍 (ASD) 患者的行为症状. 这项对八项研究的元分析表明,ASD管理的有希望的治疗途径.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 遗传学 遗传学 是一个
背景情况:
- 自闭症谱系障碍 (ASD) 与肠-大脑轴和肠道微生物群有关.
- 肠道微生物群的变化可能与ASD症状严重程度相关.
- 胃肠道和神经精神症状在ASD中很常见.
研究的目的:
- 系统地审查和元分析益生菌干预措施的有效性,以改善ASD的行为症状.
- 评估益生菌对ASD患者肠-大脑轴的影响.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 在Cochrane图书馆,PubMed,科学网和谷歌学者中进行文学搜索,截至2024年6月.
- 包括随机临床试验 (RCT),评估ASD行为症状的益生菌干预措施.
- 使用柯克兰偏差风险2的偏差评估和使用随机效应模型的统计分析.
- 使用Begg和Egger测试进行子组分析和出版偏差评估.
主要成果:
- 益生菌干预显著改善了ASD患者的行为症状 (SMD = -0.38,p < 0.01).
- 在欧洲研究 (SMD = -0.44),干预>3个月 (SMD = -0.43) 和跨年龄组 (<10岁和>10岁) 中观察到显著的好处.
- 多菌株 (SMD = -0.53) 和单菌株 (SMD = -0.28) 的益生菌都显示出显著的改善.
- 发表偏见的可能性低, robust 发现得到证实.
结论:
- 益生菌补充剂在改善与ASD相关的行为症状方面表现出显著的有效性.
- 需要个性化治疗策略和进一步的研究来确认益生菌在ASD管理中的长期有效性和安全性.
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