用手术和/或放射治疗治疗单边部治疗桃体状细胞癌
Niema B Razavian1,2, Joshua D Waltonen3, Cole R Steber4
1Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA, nrazavia@wakehealth.edu.
ORL; journal for oto-rhino-laryngology and its related specialties
|September 12, 2024
概括
治疗桃体癌的手术或辐射仅限于部的一侧显示出良好的生存和控制率. 逆侧部衰竭是罕见的,这表明这种方法对早期疾病是安全的.
科学领域:
- 在瘤学瘤学.
- 头部和部手术 头部和部手术
- 辐射瘤学 辐射瘤学
背景情况:
- 桃体癌的治疗策略正在不断发展.
- 将治疗限制在原发性瘤和两侧部是研究的一个关键领域.
- 这项研究检查了对桃体癌单边部治疗的机构经验.
研究的目的:
- 为了评估治疗桃体癌的结果与ipsilateral手术或放射治疗部管理.
- 评估用单边部方法治疗的患者的整体存活率 (OS),无进展存活率 (PFS) 和局部区域控制率 (LRC).
- 为了确定这个患者群体中逆侧部衰竭的风险.
主要方法:
- 在2012年至2020年期间治疗的71名桃腺癌患者的回顾性评估.
- 纳入标准:最终的放射治疗 (RT),手术 (S) 或手术后的放射治疗 (S-PORT) 与单边部治疗.
- 排除标准:对侧部治疗,双侧结节的参与,或转移性疾病.
- 分析包括T和N阶段,HPV状态和病理因素 (边际,ECE,LVSI,PNI).
- 卡普兰-梅尔法用于估计2年的OS,PFS和LRC.
主要成果:
- 71名患者接受了单边部治疗 (49名S,10名RT,12名S-PORT).
- 大多数人患有早期T阶段疾病 (T1/T2) 和多种N阶段; 86%是HPV阳性.
- 在27个月的中位随访期内,分别在5,6和5名患者中发生了局部,区域和远程失效.
- 没有观察到相反的部故障.
- 两年后的生存率为92%,PFS为85%,LRC为88%.
结论:
- 早期T阶段桃体癌的治疗侧重于主要瘤和两侧部,可获得可接受的生存和控制.
- 在单边治疗策略下,逆侧部衰竭的风险似乎非常低.
- 需要进一步的前性研究来确认限制治疗范围到单侧部的影响.
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