对隔膜电路的结合促使人们更喜欢与大型同行团体联系在一起
Brandon A Fricker1, Malavika Murugan2, Ashley W Seifert3
1Department of Psychology, Emory University, 36 Eagle Row, Atlanta, GA 30322, USA.
Current biology : CB
|September 12, 2024
概括
研究人员确定了一个特定的大脑电路,前带皮质 (ACC) 到侧隔膜 (LS) 路径,对于棘小鼠与大群体联系的驱动至关重要.
科学领域:
- 神经科学是一个神经科学.
- 行为生物学 行为生物学
- 动物社会行为 动物社会行为
背景情况:
- 大群体生活在动物中很常见,但基本的神经机制仍然不太了解.
- 棘鼠 (Acomys) 自然形成大社会群体,喜欢大群体.
研究的目的:
- 确定负责激励与大社会群体的关联的神经电路.
- 研究前带状皮质 (ACC) 到侧隔膜 (LS) 电路在群体归属中的作用.
主要方法:
- 鉴定了一种神经回路 (ACC-LS) 响应小组大小在刺状小鼠.
- 利用化学遗传学来操纵雄性和雌性小鼠的ACC-LS电路活性.
- 评估了电路抑制对社会和非社会关联行为的影响.
主要成果:
- ACC-LS电路在响应大小小的同行群体时显示出更大的激活.
- 这种电路的化学遗传激活影响了男女群体的研究偏好.
- 电路操纵特别影响了男性对更大群体的偏好,并削弱了社会,但不是非社会,归属.
结论:
- ACC-LS神经回路对于调节哺乳动物同龄人群归属至关重要.
- 这个电路在偏好更大的社会群体方面发挥了性别特异性的作用.
- 这些发现突出了复杂社会性进化的关键神经基础.
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