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人类母乳变异是由母亲遗传学塑造的,并影响婴儿肠道微生物群

Kelsey E Johnson¹, Timothy Heisel², Mattea Allert¹

¹Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, USA.

|September 12, 2024

概括

母亲遗传学影响人乳成分和婴儿肠道细菌. 了解牛奶基因组学与婴儿健康之间的这些联系对于个性化的婴儿营养和护理至关重要.

科学领域:

人类牛奶基因组学
哺乳期生物学哺乳期生物学
婴儿微生物组研究研究

背景情况:

母乳对于婴儿营养至关重要,但影响其成分和对婴儿健康的影响因素尚未完全理解.
缺乏对母亲遗传学,牛奶成分和婴儿健康结果之间的相互作用的系统知识.

研究的目的:

研究母体遗传学,乳腺基因表达,母乳成分和婴儿便微生物组之间的关系.
确定影响牛奶成分的遗传因素及其与母亲和婴儿健康的潜在联系.

主要方法:

对与乳腺特异性基因表达相关的遗传部位在310个哺乳期母婴对中的分析.
整合遗传数据,牛奶基因表达,牛奶成分 (包括母乳寡糖) 和婴儿便微生物群数据.
关联研究将基因表达模式与特定的牛奶成分和微生物丰度联系起来.

主要成果:

确定了482个与乳腺基因表达相关的基因位置,将它们与乳腺癌风险和人乳中的寡糖度联系起来.
发现了牛奶基因表达与婴儿肠道微生物组之间的关联,包括与炎症相关的基因表达,牛奶中的IL-6 (IL-6) 水平以及Bifidobacterium和Escherichia的丰富性之间的联系.
证明了牛奶基因表达模式与婴儿肠道微生物组成的相关性.

结论:

母亲遗传学和哺乳期乳腺的基因表达显著影响了母乳成分.
人母乳的成分受到母亲因素的影响,在塑造婴儿肠道微生物组方面发挥着作用.
了解母乳的遗传学和基因组学,为哺乳期生物学及其对母亲和婴儿健康的影响提供了关键的见解.

关键词:

母乳养哺乳期母乳养我们的eQTL是eQTL.人类牛奶是人类的牛奶.哺乳期哺乳期哺乳期微生物组是一个微生物组.营养营养营养营养

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