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Updated: Jun 13, 2025

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter
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插入介导的dsRNA结构形成与先前存在的元素作为引起疾病的机制

Emmanuelle Masson1, Sandrine Maestri1, Valérie Bordeau2

  • 1Univ Brest, Inserm, EFS, UMR 1078, GGB, 29200 Brest, France; CHRU Brest, 29200 Brest, France.

American journal of human genetics
|September 12, 2024
PubMed
概括

在SPINK1中 homozygous Alu 插入导致胰腺功能不充分,由内部 Alu 元素形成双链 RNA (dsRNA) 结构,破坏基因表达. 恢复SPINK1mRNA需要对这些Alu序列进行对齐.

关键词:
3′-UTR 记者测定试验飞行员飞行员飞行员RNA的二级结构是RNA的二级结构.这就是SPINK1的原因.异常的拼接方式双链RNA结构是双链RNA结构.dsRNARNA是什么意思全长基因表达试验试验.倒置的Alu元素是什么

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