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Published on: August 1, 2012

长期接触聚烯微塑料会减少巨细胞,并影响小鼠的微生物群-肠-大脑轴

Yue Kuai¹, Zhuoneng Chen¹, Kai Xie²

¹The Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

|September 12, 2024

概括

摄入微塑料会影响小鼠的肠道健康和行为. 小MPs促进炎症和改变肠道新陈代谢,通过微生物群-肠道-大脑轴影响身体和精神健康.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
微生物学微生物学

背景情况:

全球范围内不断增加的塑料污染涉及微塑料 (MPs),造成潜在的健康风险.
关于MPs对哺乳动物大脑和潜在机制的影响的了解有限.
以前的研究主要集中在水生物种上,哺乳动物的反应尚不清楚.

研究的目的:

为了研究长期口服MP摄入 (0.1,5,50微米) 对小鼠结肠组织的影响.
阐明MPs影响炎症和肠道健康的机制.
探索MPs对微生物群-肠-大脑轴的影响.

主要方法:

对小鼠口服不同尺寸的微塑料 (MPs).
在结肠炎相关结肠直肠癌 (CAC) 模型中评估结肠组织,炎症标志物和瘤生长.
对巨细胞和肠道微生物群组成中的VLA4-VCAM1信号通路的分析.
评估肠道新陈代谢,运动性,水的再吸收和行为变化.

主要成果:

最小的MP (0.1微米) 显示出最显著的效应.
在CAC模型中,MP的预用促进了结肠炎,但降低了瘤生长.
MPs激活了巨细胞中的VLA4-VCAM1信号,增加了炎症,后来诱导了巨细胞的减少.
聚烯MP治疗改变了小鼠的肠道新陈代谢,抑制了运动性,减少了水的再吸收,并诱导了小鼠的抑郁行为.

结论:

小MP可以诱导巨细胞的减少,影响身体和心理健康.
MPs通过改变肠道代谢和功能来调节微生物群-肠道-大脑轴.
长期暴露于MP对哺乳动物肠道健康和神经健康构成风险.

关键词:

抑郁症抑郁症抑郁症炎症炎症是一种炎症.微生物组是一个微生物组.塑料塑料的塑料的污染污染污染

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