储蓄障碍中对决策的中央和外围生理反应
Hannah C Levy1, Adam J Naples2, Sarah Collett1
1Anxiety Disorders Center, Institute of Living, 200 Retreat Avenue, Hartford, CT 06106, USA.
概括
储蓄障碍 (HD) 的神经生物学模型没有得到这项研究的支持. 在模拟丢弃任务中,与错误相关的负面性 (ERN) 和心理生理反应在患有HD的个体和对照组之间没有区别.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 积蓄障碍 (HD) 涉及持续难以丢弃财产,导致杂乱.
- 双相神经生物学模型建议在HD中减弱休息/中性状态神经系统活动和夸张的丢弃相关活动.
- 这项研究研究了HD决策的神经和心理生理相关性.
研究的目的:
- 为了比较与错误相关的消极性 (ERN) 和心理生理反应在中性和丢弃决策时,在患有HD的个体中,焦虑障碍控制和健康控制.
- 为了检查HD和对照组之间的静止状态α不对称性.
- 测试HD的双相神经生物学模型的预测.
主要方法:
- 在Go/No Go任务中比较ERN和心理生理测量 (皮肤导电性,心率变化,潮尾CO2).
- 任务包括选择中性形状和模拟丢弃报纸图像.
- 测量了静止状态α不对称性.
- 参与者包括26名HD患者,37名焦虑障碍患者和28名健康对照.
主要成果:
- 所有参与者都在犯错误时表现出增加的正面负面情绪.
- 在ERN或心理生理学措施中没有发现任何显著的群体差异.
- 休息状态α不对称性在积障碍和对照组之间没有区别.
结论:
- 这些发现不支持关于ERN和模拟丢弃任务中的心理生理学差异的拟议双相神经生物学模型.
- 无效结果可能源于使用Go/No Go任务的方法限制,以抛弃模拟.
- 需要进一步研究生态有效的丢弃任务来验证或反驳该模型.
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