Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

1.8K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
1.8K
Microtubules in Cell Motility01:24

Microtubules in Cell Motility

3.2K
Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
3.2K
Microtubule Associated Motor Proteins01:32

Microtubule Associated Motor Proteins

7.7K
Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular...
7.7K
Microtubules01:35

Microtubules

86.8K
There are three types of cytoskeletal structures in eukaryotic cells—microfilaments, intermediate filaments, and microtubules. With a diameter of about 25 nm, microtubules are the thickest of these fibers. Microtubules carry out a variety of functions that include cell structure and support, transport of organelles, cell motility (movement), and the separation of chromosomes during cell division.
86.8K
Microtubule Instability02:17

Microtubule Instability

5.0K
Microtubules are hollow cylindrical filaments having a diameter of approximately 25 nm and a length that varies from 200 nm to 25 μm. GTP-bound tubulin subunits form αβ-heterodimers for microtubule assembly. These core building blocks interact longitudinally, polymerizing into protofilaments. The protofilaments then interact with one another through lateral bonding forces to form stable cylindrical microtubules. These cylindrical filaments are dynamic as they undergo repeated...
5.0K
Destabilization of Microtubules01:45

Destabilization of Microtubules

2.6K
The destabilization of microtubules can occur during different stages of the microtubule lifecycle, such as nucleation or elongation. It can take place at either end of the microtubule or in the microtubule lattices as a whole. The lifespan of individual microtubules within a cell varies according to the cell type and stage of the cell cycle. During interphase, the lifespan of the microtubule is about 30 minutes, while during cell division, it is about 15 minutes. In axonal microtubules of...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

LRRK2 controls COX assembly through regulation of redox status of mitochondrial copper chaperones.

Redox biology·2026
Same author

A brief guide for gene delivery to the brain using adeno-associated viral vectors.

Molecules and cells·2025
Same author

Integrated proteogenomic characterization of glioblastoma evolution.

Cancer cell·2024
Same author

<i>In situ</i> silver nanoparticle development for molecular-specific biological imaging <i>via</i> highly accessible microscopies.

Nanoscale advances·2023
Same author

Functions and dysfunctions of oligodendrocytes in neurodegenerative diseases.

Frontiers in cellular neuroscience·2023
Same author

Comparing axon regeneration in male and female mice after peripheral nerve injury.

Journal of neuroscience research·2021
Same journal

Oxidative stress drives liver failure during in vivo partial reprogramming.

Molecules and cells·2026
Same journal

scpp5 regulates tooth development and injury-induced repair in zebrafish through mineralization and Wnt/β-catenin signaling.

Molecules and cells·2026
Same journal

Corrigendum to "Molecular role of developmentally regulated GTP-binding protein 1 in coordinating osteoclast and osteoblast differentiation during bone remodeling" [Mol. Cells 49 (2026) 100342].

Molecules and cells·2026
Same journal

Multiple ShKT domain-containing MUL-1 proteins act as redox-responsive modulators of oxidative stress signaling in C. elegans.

Molecules and cells·2026
Same journal

Small molecule inhibition of voltage dependent anion channel 1 reroutes mitochondrial metabolite flux.

Molecules and cells·2026
Same journal

Adherent-to-suspension transition modulates circulating tumor cell dynamics and metastatic potential in melanoma.

Molecules and cells·2026
查看所有相关文章

相关实验视频

Updated: Jun 13, 2025

Quantitative Microtubule Fractionation Technique to Separate Stable Microtubules, Labile Microtubules, and Free Tubulin in Mouse Tissues
07:21

Quantitative Microtubule Fractionation Technique to Separate Stable Microtubules, Labile Microtubules, and Free Tubulin in Mouse Tissues

Published on: November 17, 2023

1.9K

微管的功能和神经系统中的功能障碍.

Eun-Hae Jang1, Harryn Choi2, Eun-Mi Hur3

  • 1Laboratory of Neuroscience, College of Veterinary Medicine, Seoul National University, Seoul 08826, South Korea; Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, South Korea; Comparative Medicine Disease Research Center, Seoul National University, Seoul, South Korea.

Molecules and cells
|September 12, 2024
PubMed
概括
此摘要是机器生成的。

管代码,一个微管修饰系统,调节神经元结构和运输. 这种代码的破坏与神经系统疾病有关.

关键词:
神经发育 神经发育神经退行发生神经退行.后翻译修改后的修改.图布林的编码是图布林的同型为图布林.

更多相关视频

Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers
10:31

Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers

Published on: September 29, 2017

10.2K
Author Spotlight: Understanding Microtubule Network in Drosophila Neuromuscular Junctions
08:04

Author Spotlight: Understanding Microtubule Network in Drosophila Neuromuscular Junctions

Published on: October 20, 2023

2.6K

相关实验视频

Last Updated: Jun 13, 2025

Quantitative Microtubule Fractionation Technique to Separate Stable Microtubules, Labile Microtubules, and Free Tubulin in Mouse Tissues
07:21

Quantitative Microtubule Fractionation Technique to Separate Stable Microtubules, Labile Microtubules, and Free Tubulin in Mouse Tissues

Published on: November 17, 2023

1.9K
Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers
10:31

Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers

Published on: September 29, 2017

10.2K
Author Spotlight: Understanding Microtubule Network in Drosophila Neuromuscular Junctions
08:04

Author Spotlight: Understanding Microtubule Network in Drosophila Neuromuscular Junctions

Published on: October 20, 2023

2.6K

科学领域:

  • 神经科学是一个神经科学.
  • 细胞生物学 细胞生物学

背景情况:

  • 微管对于神经元的结构和功能至关重要.
  • "管蛋白代码"包括管蛋白异型和调节微管特性的翻译后修改.

研究的目的:

  • 为了回顾蛋白代码在神经系统中的作用.
  • 突出突蛋白在哺乳动物神经系统发育和维护中的翻译后修饰.
  • 探索管蛋白代码破坏与神经系统疾病之间的联系.

主要方法:

  • 文献综述侧重于蛋白编码机制.
  • 在神经元环境中分析突蛋白翻译后的修饰.
  • 检查与神经发育和神经退行性疾病的联系.

主要成果:

  • 管蛋白代码直接影响微管的稳定性,动力学和蛋白质相互作用.
  • 特定的蛋白修饰与神经系统的发育和维护有关.
  • 蛋白代码的变化与各种神经疾病有关.

结论:

  • 了解蛋白代码对于理解神经元功能和健康至关重要.
  • 对氨酸代码的进一步研究可能会揭示神经系统疾病的治疗点.