甲状腺激素相关水平与患有恶性瘤的患者的死亡率之间的关联
Ai Kimura1, Kazuhiko Kato1, Akio Nakashima1
1Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
概括
癌症患者甲状腺激素相关蛋白 (PTHrP) 水平升高与死亡率增加有关. 这项研究证实了较高的PTHrP与更差的生存结果之间的显著联系,即使考虑到水平.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 临床医学 临床医学
背景情况:
- 恶性血是癌症患者死亡率的关键预测因素.
- 由瘤分泌的副甲状腺激素相关蛋白 (PTHrP) 是已知的高血症的原因,但其与死亡率的直接联系尚未完全理解.
研究的目的:
- 为了研究血清PTHrP水平与被诊断患有恶性瘤的患者的死亡率之间的联系.
- 为了确定PTHrP水平是否影响生存预后,独立于度.
主要方法:
- 对183名患有高血症 (>10 mg/dL) 和升高的PTHrP水平 (>1.1 pmol/L) 的患者进行分析.
- 评估整体生存率,癌症诊断生存率和5年生存率.
- 考克斯的比例危险模型用于评估PTHrP对生存的影响,考虑到水平.
主要成果:
- 在PTHrP和血清水平之间发现了显著的正线性关联 (P < .001).
- 与最低水平患者相比,具有最高PTHrP水平的患者的生存率明显较低 (HR: 1.68,P = .038).
结论:
- 血清PTHrP水平与恶性瘤患者的死亡率增加显著相关.
- 即使在调整血清水平后,这种关联仍然显著,突出显示PTHrP是潜在的预后标志物.
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