社区知识图表抽象用于增强链接预测:对PubMed知识图表的研究
Yang Zhao1, Danushka Bollegala2, Shunsuke Hirose1
1Deloitte Analytics R&D, Deloitte Touche Tohmatsu LLC, 3-2-3 Marunouchi, Chiyoda-ku, Tokyo, 100-8360, Japan.
Journal of biomedical informatics
|September 12, 2024
概括
本研究引入了知识图嵌入 (KGE) 模型的扩展,用于推断缺失的生物医学知识. 这种新的方法提高了社区知识图 (CKG) 上的链接预测准确性,改善了生物医学数据分析.
科学领域:
- 生物医学信息学 生物医学信息学
- 人工智能的人工智能
- 自然语言处理自然语言处理.
背景情况:
- 生物医学知识正在迅速扩大,对现有的知识图 (KG) 进行压倒性的手册更新.
- 现有的知识图嵌入 (KGE) 方法很难在KG中捕捉属性特定的实体关系.
研究的目的:
- 提出KGE模型的扩展方法,以改善生物医学KG中的链接预测.
- 解决当前KGE方法在捕捉复杂实体关系方面的局限性.
主要方法:
- 开发了一个基于实体距离的方法,从PubMed知识图 (PKG) 中抽象社区知识图 (CKG).
- 扩展了现有的KGE模型,将PKG信息集成到抽象的CKG中,用于链接预测.
- 使用TransE,TransH,DistMult,ComplEx,SimplE和RotatE模型评估性能,使用MR,MRR和Hits@k等指标.
主要成果:
- 拟议的扩展改善了所有六个评估的KGE模型的链接预测准确性.
- 前十名的准确性显著增加,例如,RotatE.的准确性从0.76增加到0.85.
- 结果表明扩展方法的广泛适用性和有效性.
结论:
- 该研究提出了一种用于抽象CKG和增强KGE性能的新方法.
- 扩展方法显示了生物医学KG的链接预测的显著改进.
- 未来的工作包括将链接预测应用于PKG中新引入的实体.
相关概念视频
Ligand Binding and Linkage
3.0K
3.0K
Protein Networks
2.3K
2.3K
Predicting Molecular Geometry
34.1K
VSEPR Theory for Determination of Electron Pair Geometries
34.1K
Ogive Graph
5.6K
An ogive graph is sometimes called a cumulative frequency polygon. It is one type of frequency polygon that shows cumulative frequency. In other words, the cumulative percentages are added to the graph from left to right. An ogive graph plots cumulative frequency on the vertical y-axis and class boundaries along the horizontal x-axis. It’s very similar to a histogram; only instead of rectangles, an ogive displays a single point where the top right of the rectangle would be. Creating this...
5.6K
Prediction Intervals
2.2K
The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
2.2K
Improving Translational Accuracy
2.5K
2.5K


