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以PVA为基础的配方作为口服分解薄膜矩阵的设计技术平台

Marta Kozakiewicz-Latała¹, Aleksandra J Dyba¹, Dominik Marciniak¹

¹Department of Drug Form Technology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, Wroclaw, Poland.

International journal of pharmaceutics

|September 12, 2024

概括

本研究探讨了四种配方方法,以制造聚乙烯醇 (PVA) 膜,用于口服分解药物输送. 不同的技术成功地修改了PVA片中的利释放配置文件.

科学领域:

制药科学制药科学
材料科学材料科学材料科学
药物运输药物运输药物运输

背景情况:

聚合物在制药应用中至关重要,特别是在固体口服剂型中.
口服分解膜 (ODF) 为患有吞困难的患者提供了一个替代方案.
了解聚合物的特性和特征是新型药物输送系统的关键.

研究的目的:

调查不同的配方方法如何影响聚乙烯醇 (PVA) 基膜的性能.
为了优化水溶性较差的利醇 (HAL) 的分解时间和药物释放特征.
建立制造技术,薄膜特性和药物溶解行为之间的相关性.

主要方法:

配方方法包括溶剂造 (SC),3D打印 (3DP),电 (ES) 和冷化 (LP).
添加了乳酸来增强利的溶解性.
电影的特征包括形态学 (SEM,微CT),物理化学性质,热分析 (TMDSC,TGA) 和结构分析 (PXRD).

主要成果:

这四种制备技术 (SC,3DP,ES,LP) 成功地修改了PVA薄膜中利的释放.
形态,热和结构分析提供了关于薄膜特性的见解.
准备技术,薄膜结构和药物释放之间建立了相关性.

结论:

制造技术对基于PVA的ODF的特性和药物释放有很大的影响.
该研究表明,ODF制造对于控制药物溶解的适应性.
这些发现有助于选择适当的技术来开发有效的ODF,用于难以溶解的药物.

关键词:

3DP是指3DP中的一个.增材制造增材制造是一种增材制造.电子旋转是一种电子旋转.在FDM的FDM.片成型技术的技术哈洛佩里多尔 (Haloperidol) 是一种的药物.个性化治疗是个性化的治疗.软化液化化是什么意思开放式发展基金 (ODF) 是一个开放式发展基金或可分散的薄膜.使用溶剂造的方法.

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