剖析微生物分子驱动调控性B细胞分化的代谢信号通路
Maik Luu1, Felix F Krause2, Heide Monning2
1Institute for Medical Microbiology and Hygiene, Philipps-University Marburg, Marburg, Germany; Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany.
Mucosal immunology
|September 12, 2024
概括
像CpG和丁酸盐这样的细菌信号增强了调节性B细胞 (Breg) 功能. 这促进了IL-10的产生,这对于控制T细胞介导的炎症和改善宿主微生物群相互作用至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 分子生物学分子生物学
背景情况:
- 主体-微生物组轴影响抗炎性免疫反应.
- 调节性B细胞 (Bregs) 诱导共生细菌产生IL-10的机制尚不清楚.
研究的目的:
- 为了阐明由Bregs. Bregs. Bregs. Bregs. Bregs. Bregs. Bregs. Bregs. Bregs. Bregs. Bregs. Bregs. Bregs. Bregs.
- 为了确定增强Breg抗炎功能的细菌因素.
主要方法:
- 在Bregs.中研究了TLR9信号和转录因子 (Blimp-1,c-Rel).
- 进行了肠道细菌的功能查.
- 分析了短链脂肪酸 (SCFA) 和分支链脂肪酸 (BCFA) 对Bregs的影响.
主要成果:
- 细菌CpG基因激活TLR9,通过Blimp-1促进IL-10,但受到c-Rel.的抵消.
- 产生SCFA和BCFA的Clostridium sporogenes通过维持mTOR信号来增强IL-10的产生.
- 结合CpG与丁酸盐或异酸盐,协同增强了Breg IL-10的产生和抑制能力.
结论:
- 需要双重的细菌信号 (例如,丁酸盐和CpG) 才能达到最大的抗炎功能.
- 剖析的分子通路提供了对宿主微生物群相互作用的见解.
- 确定了增强抗炎细胞疗法的潜在策略.
相关概念视频
B Cell Activation and Differentiation
1.6K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.6K
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Diversity in Cell Signaling Responses
6.4K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity.
Graded and Abrupt Responses
Some signaling systems generate...
Graded and Abrupt Responses
Some signaling systems generate...
6.4K
Bacterial Signaling
31.8K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
31.8K
NF-κB-dependent Signaling Pathway
7.4K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.4K
Signal Transduction: Overview
8.3K
Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
Typically, signal transduction involves three...
8.3K


