在正常衰老和认知中大脑结构-功能合之间的关系:一个跨种族基于人口的研究
Chang Liu1, Jing Jing2, Jiyang Jiang3
1Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
NeuroImage
|September 12, 2024
概括
随着年龄的增长,大脑结构-功能合会减弱,影响认知功能. 这项研究引入了一个新的指数来测量这种合,提供了对老化大脑机制和神经疾病潜在早期诊断的见解.
科学领域:
- 神经科学是一个神经科学.
- 脑部成像 脑部成像
- 认知老龄化 认知老龄化
背景情况:
- 了解大脑结构和功能如何相互作用,对于解释认知行为至关重要.
- 老化大脑中的结构功能合的精确性质在很大程度上是未知的.
研究的目的:
- 开发和验证一个新的索引,脑结构连接体和功能连接体 (C-BSF) 索引的合.
- 量化老龄化个体的区域结构-功能合.
- 研究结构-功能合,年龄和认知表现之间的关系.
主要方法:
- 使用的扩散张力成像 (DTI) 和静止状态功能磁共振成像 (fMRI) 数据.
- 分析了来自两个大型队列的数据:PRECISE研究 (n=2007) 和MAS队列 (n=254).
- 计算了C-BSF指数,以评估不同大脑网络的结构-功能合.
主要成果:
- 结构-功能合在大脑网络中各不相同,在视觉网络中最强,在腹部注意力网络中最弱.
- 较弱的结构功能合与晚年和较差的认知状态相关.
- 视觉网络中的合减少与视觉空间性能有关,并部分解释了年龄对视觉空间功能的影响.
结论:
- C-BSF指数为评估老化中的大脑结构功能完整性提供了有价值的指标.
- 衰老与大脑结构功能合的减弱有关,导致认知能力下降.
- 这些发现可以为与年龄相关的神经疾病的早期诊断和治疗策略提供信息.
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