血清维生素D,和性功能障碍妇女的氧化应激水平之间的关系:一个病例对照研究
Mohammadreza Rafati1, Elahe Bazrafshan2, Fatemeh Shaki3
1Department of Clinical Pharmacy, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Taiwanese journal of obstetrics & gynecology
|September 12, 2024
概括
维生素D缺乏与女性性功能障碍 (FSD) 有关. 补充剂改善了女性的性功能,水平,并减少了FSD的氧化应激.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 营养科学 营养科学
背景情况:
- 女性性功能障碍 (FSD) 是一种普遍的疾病,可能与低维生素症有关.
- 维生素D在骨健康之外发挥作用,影响氧化应激和脂质过氧化.
- 在患有FSD的女性中观察到血清维生素D水平较低.
研究的目的:
- 在患有FSD的女性中,研究血清维生素D,和氧化应激标志物之间的关系.
- 评估维生素D补充剂在改善性功能和相关生物标志物的有效性.
主要方法:
- 一项涉及40名患有FSD的女性 (18-45岁) 的横截面研究,分为干预组和对照组.
- 干预组接受了维生素D (300,000 IU IM,然后每周口服50,000 IU,持续4周).
- 血清维生素D,,氧化应激标志物 (谷氨,TAC,MDA,蛋白碳酸,氧化) 和女性性功能指数 (FSFI) 分数在基线和三个月的每月测量.
主要成果:
- 与对照组相比,维生素D干预组的血清丸激素水平 (P=0.014) 和FSFI得分 (P<0.01) 显著增加.
- 血清维生素D水平与谷氨,总抗氧化能力 (TAC),和FSFI分数之间观察到正相关性.
- 在血清维生素D水平和麦隆迪甲基 (MDA),蛋白质碳和氧化之间发现了负相关性,表明氧化应激减少.
结论:
- 低维他命症D与女性性功能障碍有关.
- 维生素D补充剂是FSD的潜在治疗选择.
- 补充剂有效地提高了丸激素水平,减少了氧化应激,并在患有FSD的女性中增强了性功能.
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