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系统性红斑狼患者的拓结构特征,有或没有神经精神病症状
Feng Ao1,2, Li Su3, Yunyun Duan1
1Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Lupus science & medicine
|September 12, 2024
概括
系统性红斑狼 (SLE) 改变了大脑网络,神经精神病症状 (NPSLE) 患者的变化更为显著. 这些大脑网络的改变可以作为诊断生物标志物.
科学领域:
- 神经成像是一种神经成像.
- 系统神经科学 系统神经科学
- 类风湿病学 类风湿病学
背景情况:
- 系统性红斑狼 (SLE) 是一种自身免疫性疾病,可能涉及神经系统.
- 神经精神症状 (NPSLE) 复杂化SLE诊断和管理.
- 了解SLE中大脑结构网络的改变至关重要.
研究的目的:
- 在有或没有神经精神症状的SLE患者中调查拓结构大脑网络特征 (NPSLE与非NPSLE).
- 探索这些网络变化的临床影响和诊断潜力.
主要方法:
- 用MRI扩散张力成像在50名SLE患者和32名健康对照中构建结构性大脑网络.
- 计算了全球和本地网络指标,并进行了群组比较.
- 使用支持矢量分类来区分NPSLE和非NPSLE组.
主要成果:
- 与对照组相比,非NPSLE和NPSLE患者都显示出显著的全球和本地拓脑网络改变.
- NPSLE患者表现出更明显的变化,特别是在默认模式和感觉运动网络.
- 网络变化与疾病持续时间,病变负担和诊断指数相关,使NPSLE和非NPSLE之间有87%的准确差异化.
结论:
- 在SLE患者中,结构性大脑网络在全球和本地发生变化,而NPSLE显示出更严重的变化.
- 默认模式和传感器运动网络在NPSLE中受到显著影响.
- 这些拓变化显示出SLE诊断的潜在生物标志物.
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