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调查色彩视觉及其结构相关物15年后的第一个脱髓化事件

Charmaine Yam¹, Wallace J Brownlee², Ferran Prados Carrasco³

¹Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, London, UK c.yam@ucl.ac.uk.

Journal of neurology, neurosurgery, and psychiatry

|September 12, 2024

概括

长期的色彩视觉障碍即使在第一个脱髓化事件发生15年后的未受影响的眼睛中也会发生,特别是在渐进的多发性硬化症 (MS) 中. 质细胞内状层 (GCIPL) 稀薄,表明神经轴损失,是这种视力缺陷的基础.

科学领域:

神经眼科神经眼科
神经免疫学神经免疫学
视觉科学视觉科学视觉科学

背景情况:

研究的长期视觉结果是第一个脱髓化事件发生后15年.
使用光学连贯断层扫描 (OCT) 和脑MRI检查的结构相关性.

研究的目的:

在第一次脱髓化事件后,评估患者的长期色彩和对比视力.
为了将视觉结果与OCT和MRI发现以及多发性硬化症 (MS) 现型相关联.

主要方法:

招募的患者是他们第一次脱髓化事件后的15年.
进行了临床评估,OCT和脑MRI;分类MS表型.
利用线性混合模型分析视觉结果,MS表型和OCT措施之间的关联.

主要成果:

在平均14.3年后评估了94名患者;研究了111只视神经炎 (ON) 眼睛和77只不受影响的眼睛.
ON眼睛的色彩视力比不受影响的眼睛更差.
与临床隔离综合征 (CIS) 相比,不受影响的眼睛在复发性复发性多发性硬化症 (RRMS) 和二次渐进性多发性硬化症 (SPMS) 中的色彩视力更差. 质细胞内状层 (GCIPL) 厚度预测视觉结果比周状视网膜神经纤维层 (pRNFL) 更好. 较差的色彩视觉与较低的视网膜厚度和较高的大脑T2损伤负载相关.

结论:

在未受到影响的眼睛中,色彩视力障碍明显,特别是在SPMS中,与GCIPL稀释 (神经轴损失) 相关.
较差的色彩视觉与增加的T2病变负载相关,这表明它反映了整体疾病负担.
定量色彩视觉评估与OCT一起可能有助于评估第一个脱髓化事件后的疾病严重程度.

关键词:

多发性硬化多发性硬化神经瘤学神经瘤学视觉视觉视觉是一个视觉.

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