[糖尿病对支气管切除症的影响]
1Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China.
概括
支气管切除症患者的糖尿病与较差的营养状况,更严重的症状和急性恶化的风险增加有关. 由于这种情况,这些患者也面临更高的财务负担.
科学领域:
- 肺部病理学 肺部病理学
- 内分泌学 在内分泌学.
- 临床医学 临床医学
背景情况:
- 支气管切除症是一种慢性呼吸道疾病.
- 糖尿病是一种代谢障碍,具有显著的系统影响.
- 支气管切除症和糖尿病之间的相互作用需要进一步研究以了解临床结果.
研究的目的:
- 为了研究患有支气管切开症和并发性糖尿病的患者的临床特征和疾病严重程度.
- 为了比较支气管切除症和糖尿病患者与单独支气管切除症患者之间的结果.
- 为了确定与患有糖尿病的支气管切除症患者疾病严重程度相关的因素.
主要方法:
- 从上海肺部医院 (2017-2021) 的1310名支气管切除症住院患者的回顾性分析.
- 倾向性得分匹配 (1:4比) 用于比较78名支气管和糖尿病患者与269名无糖尿病支气管患者.
- 使用t测试,非参数测试和千平方测试对临床特征,实验室结果,感染和疾病严重程度进行比较分析.
主要成果:
- 支气管切除 - 糖尿病组年龄较大,表现出较低的前白蛋白水平,表明营养状况较差.
- 支气管切除症和糖尿病患者的医学研究委员会 (mMRC) 修改得分显著更高,因恶化而住院的频率增加,支气管切除症严重性指数 (BSI) 得分更高.
- 在支气管切除-糖尿病组中观察到更高的住院费用. 禁食血糖,尿液葡萄糖和BSI得分与疾病严重程度有积极的相关性,而前白蛋白显示出负相关性.
结论:
- 支气管切除症患者的并发性糖尿病与较差的营养状况,更严重的呼吸道症状和急性恶化风险更高有关.
- 糖尿病会加剧支气管切除症的严重程度,由较高的BSI得分和医疗保健利用率的增加表明.
- 有效的糖尿病管理对于改善治疗结果和减轻支气管病患者的负担至关重要.
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