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IL-4驱动CD8+CART细胞的耗尽

Carli M Stewart1,2,3, Elizabeth L Siegler1,4, R Leo Sakemura1,4

  • 1T Cell Engineering, Mayo Clinic, Rochester, MN, USA.

Nature communications
|September 12, 2024
PubMed
概括

介质素-4 (IL-4) 驱动着仿真抗原受体T (CART) 细胞疲劳,限制了治疗的有效性. 准IL-4通路或使用IL-4抗体可以增强CART细胞功能和抗瘤功效.

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