同时服用米达佐拉姆和 псилоцибин:对心理经验的主观质量和记忆的差异性影响
Christopher R Nicholas1,2, Matthew I Banks3,4,5, Richard C Lennertz2,6
1Department of Family Medicine and Community Health, School of Medicine and Public Health, University of Wisconsin, Madison, WI, 53706, USA.
Translational psychiatry
|September 12, 2024
概括
记忆 psilocybin 经验,而不仅仅是急性影响,可能有助于其治疗效益. 使用米达佐拉姆降低了洞察力和福祉的感觉.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 临床心理学 临床心理学
背景情况:
- 诸如 псилоцибин之类的血清色精神药物显示出对精神疾病的治疗潜力.
- 西的急性主观体验与积极的结果有关,但记忆的作用尚不清楚.
研究的目的:
- 为了调查是否记忆psilocybin的经验有助于其治疗效果.
- 为了确定记忆障碍是否影响了psilocybin管理的主观和心理结果.
主要方法:
- 健康的参与者接受了松素 (25毫克) 结合米达佐拉姆,一种具有记忆缓解功能的 benzodiazepine.
- 调整了米达佐拉姆的剂量,以允许有意识的迷幻体验,同时部分损害记忆力.
- 主观体验和记忆回忆在服用剂量当天被评估.
主要成果:
- 确定了一剂米达佐拉姆剂量,允许在部分记忆障碍的情况下有意识地体验psilocybin.
- 更高的米达佐拉姆剂量和更大的记忆障碍与显著性,洞察力和幸福感的减少有关.
- 这些发现表明,记忆的形成在psilocybin的行为影响中起作用.
结论:
- 记忆psilocybin经验似乎是其治疗潜力的因素.
- 米达佐拉姆对记忆的影响,可能是通过阻断神经可塑性,可以用来研究心理药物对治疗的神经可塑性贡献.
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