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Updated: Jun 13, 2025

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一个单域抗体向XII因子可以抑制血栓形成和炎症

Pengfei Xu1, Yingjie Zhang1, Junyan Guo1,2

  • 1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Nature communications
|September 12, 2024
PubMed
概括

在小鼠模型中,因子XII (FXII) 阻塞与一种新的纳米体-Fc融合蛋白 (Nb-Fc) 有效地减少了血栓形成和炎症. 这种FXII抑制对治疗血栓炎性疾病 (如血管炎) 和ECMO支持期间的治疗有希望.

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