合成,表征和生物活动的新一类的sonochemically合成Cu2+复合体
Hamed Ghanbari1, Hossein Derakhshankhah2, Kiumars Bahrami3,4
1Department of Organic Chemistry, Faculty of Chemistry, Razi University, Kermanshah, 67144-14971, Iran.
Scientific reports
|September 12, 2024
概括
通过声化学合成的两种新型铜复合物显示出显著的抗氧化剂和低细胞毒性,表明药物输送和癌症治疗应用的潜力.
科学领域:
- 超分子化学 超分子化学
- 协调化学 协调化学
- 材料科学 材料科学 材料科学
- 生物医学应用 生物医学应用
背景情况:
- 金属复合物,特别是铜复合物,在各种科学和生物医学领域都至关重要.
- 了解新型金属复合物的合成,结构和生物活性对于开发新的治疗剂至关重要.
研究的目的:
- 通过声化学方法合成和表征两种新的铜 (Cu) 复合物.
- 研究合成的铜复合物的结构,光谱和生物特性.
- 评估它们在药物输送和癌症治疗中的潜在应用.
主要方法:
- 铜复合物的声化学合成.
- 使用单晶X射线衍射,FTIR,PXRD,TGA/DTA,SEM,TEM和EDS进行结构性表征.
- 生物活性评估包括抗氧化剂测定,血液溶解测试和细胞毒性评估.
主要成果:
- 两种新型铜复合物[Cu(L) ((L) ((H2O) 2) (1) 和[Cu(L) ((Im) H2O] (2) 已成功合成.
- 复合体 (1) 具有六坐标的Cu2+离子,而复合体 (2) 具有五坐标的Cu2+离子,具有不同的晶体结构 (单临床和三临床).
- 这两种复合物都表现出显著的抗氧化活性,非溶血性行为 (<2%的溶血),以及对纤维细胞和MCF-7细胞系的低细胞毒性,但缺乏抗菌活性.
结论:
- 合成的铜复合物具有有前途的抗氧化剂和低毒性特征.
- 它们独特的超分子结构,通过键和π-π堆叠稳定,有助于它们的特性.
- 这些铜复合体显示出在药物输送系统和癌症治疗中发展的潜力.
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