对于细胞适应每日温度波动,HSF1是必要的
Ryosuke Takii1, Mitsuaki Fujimoto1, Akanksha Pandey1
1Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Minami-Kogushi 1-1-1, Ube, 755-8505, Japan.
Scientific reports
|September 12, 2024
概括
热冲击转录因子1 (HSF1) 在日常温度变化期间对人类细胞存活至关重要,与HSF3.3不同. 这凸显了HSF1在适应波动的环境方面的独特作用.
科学领域:
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
- 进化生物学是进化的生物学.
背景情况:
- 热冲击反应 (HSR) 是细胞对热应激的基本适应.
- 热冲击转录因子1 (HSF1) 和HSF3调节脊椎动物内热体中的HSR.
- 与其他哺乳动物相比,产卵哺乳动物 (单体动物) 的体温调节能力较低.
研究的目的:
- 研究HSF1和HSF3在细胞适应温度波动中的作用.
- 为了比较不同脊椎动物群的HSF1和HSF3的HSR诱导潜力.
- 确定HSF1在人类细胞适应每日温度变化中的特定功能.
主要方法:
- 从单体动物和鸟类中对HSF1和HSF3进行比较分析.
- 在HSF1-null人体细胞中进行功能性测试.
- 对HSF1目标基因的基因表达分析.
主要成果:
- 单体HSF1和HSF3可以最大限度地诱导HSR,而鸟类HSF1或HSF3单独具有这种潜力.
- 来自脊椎动物的HSF1,但不是HSF3,在HSF1-零的人类细胞中恢复了热电阻.
- HSF1的保护功能与特定目标基因的上调相关,独立于热冲击蛋白诱导.
结论:
- HSF1在细胞适应日常温度波动的环境方面发挥着独特的作用.
- 脊椎动物HSF基因的功能分歧与恒温能力的演变有关.
- 在波动的热条件下,HSF1对人类细胞的增殖和生存至关重要.
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