相关实验视频
Updated: Jun 13, 2025
08:40
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
7.0K
在炎症性肠病中睡眠障碍的患病率和危险因素:一个横截面研究
Jin-Zhi Zhang1,2, Xiao-Zhen Song3, Xiao-Na Song1,2
1Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China.
International journal of colorectal disease
|September 12, 2024
概括
睡眠障碍在炎症性肠病 (IBD) 患者中很常见,影响近60%. 吸烟和抑郁症是显著的危险因素,而更高的BMI可能是保护性的.
科学领域:
- 胃肠病学 胃肠病学
- 睡眠医学 睡眠医学
- 公共卫生 公共卫生
背景情况:
- 睡眠障碍是一个重大的公共卫生问题,可能会使炎症性肠病 (IBD) 患者的炎症和疾病活动恶化.
- 睡眠质量受损是IBD患者的常见问题,需要对其患病率和促成因素进行调查.
研究的目的:
- 确定被诊断患有炎症性肠病 (IBD) 的患者睡眠障碍的患病率.
- 确定与IBD患者睡眠障碍发展相关的关键风险因素.
主要方法:
- 匹兹堡睡眠质量指数 (PSQI) 用于在2023年3月至2024年2月期间评估208名IBD患者和199名健康对照者的睡眠质量.
- 进行了单变量和多变量分析,以确定IBD队列中睡眠障碍的显著风险和保护因素.
主要成果:
- 在59.6%的IBD患者中诊断出睡眠障碍,与健康对照 (37.7%) 相比,患病率明显高.
- 多变量分析确定老年 (OR 1.070),吸烟 (OR 2.698) 和抑郁症 (OR 4.779) 是IBD患者睡眠障碍的重要危险因素.
- 发现较高的体重指数 (OR 0.879) 是该人群中对睡眠障碍的保护因素.
结论:
- 睡眠障碍在患有炎症性肠病 (IBD) 的患者中非常普遍,无论疾病的活性如何.
- 吸烟和抑郁症被确定为主要可改变的风险因素,有助于IBD患者的睡眠障碍.
相关概念视频
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
153
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
153
01:30Inflammatory Bowel Disease II: Crohn's Disease
201
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
201
01:17Chronic Bowel Disorders: Introduction
410
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
410
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
324
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
324
01:17Irritable Bowel Syndrome I: Introduction
257
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
257
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
98
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
98