在COVID-19中使用nirmatrelvir/ritonavir治疗后的临床复苏
Daniel Camp1,2, Matthew Caputo1, Fabiola Moreno Echevarria1,2
1Robert J. Havey Institute for Global Health, Feinberg School of Medicine, Northwestern University, 710 N Lake Shore Drive, Chicago, IL, 60611, USA.
BMC infectious diseases
|September 12, 2024
概括
尼马特里尔维尔/里托纳维尔 (NM/r) 治疗后的COVID-19临床反弹比以前认为的更为常见,影响6.0%的患者. 复发病例通常是温和的,结果有利,这表明住院率低.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 尼尔马特雷尔维尔/里托纳维尔 (NM/r) 是一种有效的口服抗病毒药物,用于治疗轻度至中度的COVID-19.
- 报告了临床反弹综合征,其特征是治疗后症状复发.
- 有限的数据存在于NM/r相关的COVID-19反弹频率,有助于的因素,以及日常护理的结果.
研究的目的:
- 为了确定NM/r治疗后COVID-19临床反弹的频率.
- 确定与反弹相关的潜在人口和临床因素.
- 为了评估COVID-19复发的临床结果.
主要方法:
- 对268名成年患者进行了回顾性电子病历审查,这些患者接受了NM/r治疗.
- COVID-19临床反弹的定义:症状改善,随后在5天的NM/r疗程后30天内复发/恶化.
- 对人口统计数据,并发病,疫苗接种情况和先前感染情况的分析.
主要成果:
- 6% (16/268) 的患者经历了COVID-19的临床反弹.
- 在开始NM/r后,反弹的中位时间为11天.
- 在女性,黑人患者,并发病患者和没有先前感染SARS-CoV-2的人群中观察到更高比例的反弹 (尽管在统计学上不显著).
- 只有一个患者 (6.25%) 在反弹后被住院治疗.
结论:
- 在NM/r后的COVID-19临床反弹在现实环境中比以前报告的更频繁.
- 复发病例表现出轻微的症状和有利的临床结果,住院率低.
- 进一步的研究可能会澄清导致因素,并优化管理策略.
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