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Updated: Jun 13, 2025

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空间转录学揭示了瘤衍生的SPP1诱导纤维细胞化学反应和激活在肝细胞癌微环境中的微环境

Wen Tong¹, Tianze Wang², Yi Bai³

¹The First Central Clinical School, Tianjin Medical University, Tianjin, 300070, China.

Journal of translational medicine

|September 12, 2024

概括

研究人员发现,瘤细胞分泌SPP1,在肝星细胞 (HSC) 上激活CD44,驱动它们分化为癌症相关纤维细胞 (CAF) 并促进肝癌的生长.

科学领域:

在瘤学瘤学.
细胞生物学细胞生物学
癌症研究癌症研究

背景情况:

瘤微环境 (TME) 显著影响癌症进展和治疗结果.
在肝细胞癌 (HCC) 中,TME内的癌症相关纤维细胞 (CAF) 促进瘤生长和侵入.
在HCC中控制瘤细胞-CAF相互作用的机制尚未完全理解.

研究的目的:

阐明驱动HCC瘤细胞和CAF之间的相互作用的分子机制.
在HCC TME中确定参与CAF激活的关键信号通路.

主要方法:

来自HCC的空间和单细胞转录组学数据的分析.
对临床肝癌患者样本的检查.
在体外和体内实验来研究SPP1-CD44信号轴.

主要成果:

表达高SPP1的瘤细胞定位在肝星细胞 (HSC) 附近.
SPP1-CD44相互作用激活PI3K/AKT通路,促进HSC与CAF的分化.
阻断CD44或沉默SPP1会抑制HSC的分化,减少瘤体积和树突原蛋白.

结论:

在HCC中,SPP1-CD44信号轴对于瘤细胞-CAF通信至关重要.
准这种途径可能会减少肝纤维化,并为肝癌提供新的治疗策略.

关键词:

与癌症相关的纤维细胞.肝细胞癌是肝细胞癌.SPP1 SPP1 这是一个很好的选择.单细胞RNA测序的一个细胞.空间转录组学空间转录组学

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The Tumor Microenvironment

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