禁食脂质和葡萄糖度与ALT水平之间的强烈关联随着ALT量度的增加而得到加强
Wei Liu1, Lipu Shi1, Mengmeng Yuan2
1Department of Rheumatology and Clinical Immunology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, China.
禁食的血脂和葡萄糖水平与肝脏酶氨酸转胺酶 (ALT) 和酸氨酸转胺酶 (AST) 有关. 较高的脂质和葡萄糖水平与肝酶的增加相关,这表明潜在的亚临床肝损伤由代谢失衡.
科学领域:
- 代谢健康和肝功能.
- 心血管和代谢疾病研究研究.
- 肝损伤的生物标志物
背景情况:
- 由于碳水化合物和脂质代谢不平衡,持续的氧化应激会损害肝脏.
- 禁食脂质和葡萄糖水平以及肝酶 (ALT,AST) 之间的关系需要进行大规模的人口研究.
研究的目的:
- 在大量人群中,研究空腹血脂和葡萄糖度与空腹血中ALT和AST水平之间的关联.
- 探索这些关联中的潜在基于性别的差异.
主要方法:
- 这是一项对182,971名年龄在18~92岁之间的个体进行的横截面研究.
- 使用了多维分层分析,包括定量线性回归和性别分层.
- 研究了非HDL-C,甘油三,HDL-C,葡萄糖和ALT/AST水平之间的关联.
主要成果:
- 在非HDL-C,甘油三水平和ALT之间发现了积极的关联,在男性中更强.
- HDL-C和ALT之间的负相关性,在男性中也更强.
- 葡萄糖和ALT之间的积极关联,在女性中更强.
- 类似的模式,虽然较弱,观察到AST.
- 专水平在脂质和葡萄糖度之间保持稳定.
结论:
- 血脂/葡萄糖水平和肝酶之间存在剂量依赖的关系,这表明潜在的亚临床肝损伤来自代谢失调.
- 持续的肝炎可能会导致心脏,脏和肺部等邻近器官的病理.
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