在不同温度下在不同的 {碳醇 + 水} 混合物中对阿塞克洛芬雅克的溶解性和热力学分析
Faiyaz Shakeel1, Ramadan Al-Shdefat2, Mohammad A Altamimi1
1Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
BMC chemistry
|September 12, 2024
概括
抗炎药物aceclofenac (ACF) 的溶解性在卡比托-水混合物中显著增加,由温度和卡比托度决定. 这项研究强调了碳醇.
科学领域:
- 物理化学 物理化学
- 制药科学 制药科学
背景情况:
- 阿塞克洛芬雅 (ACF) 是一种广泛使用的非类固醇抗炎药物.
- 了解其溶解度对于开发有效的药物输送系统至关重要.
- 同溶剂系统可以显著改变药物的溶解性和热力学特性.
研究的目的:
- 为了研究阿塞克洛芬亚克 (ACF) 在各种2 - - - 2 - - 乙氧乙乙醇 (Carbitol) + 水混合物中的溶解性和热力学行为.
- 为了评估温度和碳醇度对ACF溶解性的影响.
- 评估控制ACF溶解和溶解的热力学参数.
主要方法:
- 在298.2 K至318.2 K的温度下使用摇法确定溶解度.
- 使用多个热力学模型验证实验数据 (范特霍夫,阿佩尔布拉特,乔伊班-阿克里等). ) 的情况.
- 计算热力学参数,如溶解的和.
主要成果:
- 实验可溶性数据与计算模型有很强的一致性 (误差<3.0%).
- 随着温度和混合物中碳酸盐质量分数的增加,ACF的溶解性增加了.
- 溶解度在纯水中最低,在纯碳醇中最高.
- 溶解是内热和驱动的,控制溶解.
结论:
- 卡尔比托尔显著增强了阿塞克洛芬的水溶性.
- 该药物与水相比,与碳醇具有更强的分子相互作用.
- 碳醇是一种有前途的辅溶剂,可以提高ACF的溶解度和配方.
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