两种不同的预加载目标对移植期间中风体积变化的比较:一项随机对照试验
Seong-Mi Yang1, Seung Eun Song2, Ji-Yoon Jung2,3
1Department of Anesthesiology and Pain Medicine, Asan Medical Center, Seoul, Republic of Korea.
Singapore medical journal
|September 13, 2024
概括
维持足够的预负载,并以6%或12%的中风体积变化 (SVV) 目标保持足够的移植 (KT) 移植功能. 对于已故的捐赠者KT,需要进一步的研究.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植手术 移植手术
- 关键护理医学 关键护理医学
背景情况:
- 充足的预负载对于移植 (KT) 的移植功能至关重要.
- 动态预装载指数,如冲击体积变化 (SVV),指导流体管理.
- 对活体供体KT的最佳SVV标仍在调查中.
研究的目的:
- 评估高 (12%) 与低 (6%) 的SVV正常标对活体供体KT期间对移植功能的影响.
- 根据不同的SVV目标,比较血液动力学管理策略.
主要方法:
- 一个随机试验比较SVV6% (n=30) 和SVV12% (n=30) 组.
- 以SVV目标为指导的液体 (晶体) 管理.
- 与中性粒细胞凝酶相关的利波卡林 (NGAL) 水平,延迟移植功能 (DGF) 发生率,血清肌氨酸和KT后的膜过率 (GFR) 的比较.
主要成果:
- 群体之间晶类药物给药的显著差异 (SVV6%接受了更多).
- 在SVV6%和SVV12%组之间,NGAL水平,DGF发生率或术后血清肌和GFR没有显著差异.
- 两种SVV目标都显示了对移植功能的可比结果.
结论:
- 6%或12%的SVV目标值足以用于活体供体KT的预负载管理.
- 由于DGF的发病率很低,并有可能出现II型错误,因此应该谨慎地解释该研究的结果.
- 需要进一步的研究,特别是对已故的捐赠者KT进行进一步的研究,以证实这些发现.
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