HER2状态导致从原发性乳腺癌转变为复发性乳腺癌的不稳定转换
Anjie Zhu1, Nan Wang1, Zehui Yun1
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology, Peking University Cancer Hospital and Institute, Beijing, China.
Neoplasma
|September 13, 2024
概括
乳腺癌中的HER2表达高度不稳定,主要和复发性瘤之间存在显著的不一致. 这种不稳定性在激素受体阳性患者中更为明显,影响治疗决策.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 乳腺癌研究研究 乳腺癌研究
背景情况:
- 准确的HER2 (人类表皮生长因子受体2) 测试对于乳腺癌治疗决策至关重要.
- 通过免疫组织化学 (IHC) 来区分HER2-2+和HER2-0/1+瘤具有挑战性.
- 一般认为HER2 IHC 2+表示中度表达,结果可靠.
研究的目的:
- 评估原发性和复发性乳腺癌之间HER2-2+表达的不一致性.
- 评估HER2-2+瘤患者HER2表达状态的稳定性.
- 分析影响HER2表达异调的因素,包括激素受体状态.
主要方法:
- 在原发性或复发性瘤样本中对159名表达HER2-2+的患者进行了回顾性分析.
- 使用免疫组织化学 (IHC) 和局部杂交 (ISH) 评估HER2状态.
- 在初级和配对复发性/转移性疾病样本之间的HER2表达的比较.
主要成果:
- 在原发性和复发性瘤之间,HER2 IHC整体异常率为67.1%.
- 在44.0%的原发性瘤和88.8%的复发性瘤中观察到HER2-2+表达.
- 与荷尔蒙受体阴性患者 (21.7%) 相比,荷尔蒙受体阳性患者 (44.1%) 的不和更为频繁.
- HER2表达高度不稳定,经常在HER2-2+,HER2-1+和HER2-0状态之间切换.
结论:
- 乳腺癌中的HER2表达高度不稳定,显示了原发性和复发性疾病之间的显著不一致.
- 异常的高率,特别是在HR阳性乳腺癌中,需要在复发时仔细重新评估HER2状态.
- 临床管理策略可能需要考虑乳腺癌中HER2表达的动态性.
更多相关视频
11:34Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
Published on: December 5, 2017
12.6K
08:29Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells
Published on: May 9, 2025
86
相关概念视频
02:07Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
02:38Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K