肝移植中的抗体介导排斥:免疫病理特征和长期随访
Luca Cicalese1, Zachary C Walton2, Xiaotang Du3
1Division of Transplant Surgery, Department of Surgery, University of Texas Medical Branch, UTMB, Galveston, TX, United States.
概括
诊断肝脏抗体中介排斥 (AMR) 是很困难的. 早期检测和及时治疗AMR,涉及捐赠者特异性抗体 (DSA),对于预防移植失败和改善患者结果至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 移植免疫学 移植免疫学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 肝脏抗体中介排斥 (AMR) 诊断具有挑战性,并且往往未得到充分承认.
- 抗药性耐药性,捐赠者特异性抗体 (DSA),病理学和临床结果之间的关系需要进一步定义.
研究的目的:
- 根据2016年班夫标准,识别和描述肝脏AMR病例.
- 分析肝脏AMR患者的临床过程,治疗策略和结果.
主要方法:
- 使用2016年班夫标准对肝脏AMR病例的回顾性鉴定.
- 收集和分析患者的人口统计数据,原始肝病,组织病理学,治疗细节,临床结果和转氨酶水平.
主要成果:
- 确定了8名AMR患者,其中7人符合班夫标准.
- 个性化治疗包括免疫抑制优化,类固醇,血合成,IVIG,rituximab和 bortezomib.
- 五名患者实现了AMR的完全解决,而一名患者出现了慢性AMR,两名患者需要重新移植.
结论:
- 在转氨酶升高时,通过交叉匹配,活检和DSA监测对AMR的早期检测至关重要.
- 及时治疗对于逆转AMR,预防移植失败,慢性损伤,再移植和死亡至关重要.
关键词:
抗菌药物反症 (AMR) 是一种C4d C4d 是一个词.DSA DSA DSA DSA DSA DSA DSA DSA DSA DSA DSA DSA DSA DSA DSA DSA DSA DSA DSA DSA所有的移植.拒绝 拒绝 拒绝 拒绝实体器官移植 实体器官移植更多相关视频
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