在23个月的恩特卡维尔预防后,B型肝炎病毒的再激活
Caleb J C McKinney1, William Bigelow2, Preethi G Venkat2
1Department of Internal Medicine, University of Virginia, Charlottesville, VA.
ACG case reports journal
|September 13, 2024
概括
乙型肝炎病毒 (HBV) 再激活可能在CAR T细胞治疗后晚发生,即使有抗病毒预防措施. 这一案例强调了在接受CAR T细胞治疗的患者中对HBV进行扩展监测和优化预防策略的需要.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 在瘤学瘤学.
背景情况:
- 乙型肝炎病毒 (HBV) 再激活是免疫抑制患者的风险.
- 化学抗原受体 (CAR) T细胞治疗可以导致显著的免疫抑制.
- 在CAR后的HBV再激活T细胞疗法是记录的,但缺乏具体的指导方针.
研究的目的:
- 报告一个在CAR T细胞治疗后晚期HBV重新激活的独特病例.
- 强调需要进一步研究HBV再激活风险和CAR T细胞治疗后的预防.
主要方法:
- 病例报告详细介绍了患者与HBV重新激活的经验.
- 审查患者的治疗史,包括CAR T细胞治疗和恩特卡维尔预防.
主要成果:
- 在CAR T细胞输液后27个月,该患者经历了HBV活性化.
- 尽管进行了23个月的连续恩特卡维尔预防,但发生了重新激活.
结论:
- 晚期HBV再激活是可能的,即使在CAR-T细胞治疗后进行长期恩特卡维尔预防.
- 目前的预防策略可能对一些患者来说不足.
- 需要进行进一步的研究,以建立最佳的HBV监测和预防方案,用于接受CAR T细胞治疗的患者.
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