联合,和与全身炎症的关联
Emmanuel Obeng-Gyasi1,2, Barnabas Obeng-Gyasi3
1Department of Built Environment, North Carolina A&T State University, Greensboro, NC, United States.
Frontiers in public health
|September 13, 2024
概括
环境金属暴露,特别是,与全身炎症有关. 这项研究使用了先进的方法来分析复杂的金属混合物及其对C反应蛋白 (CRP) 水平的影响.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 生物统计学 生物统计学
背景情况:
- 环境金属暴露与全身炎症和慢性疾病有关.
- 了解金属混合物对健康的综合影响仍然是一个挑战.
研究的目的:
- 评估,和对C反应蛋白 (CRP) 水平的单独和联合影响.
- 利用国家健康和营养检查调查 (NHANES) 2017-2018年的数据.
主要方法:
- 贝叶斯核机器回归 (BKMR) 分析非线性暴露-反应函数和金属相互作用.
- 后置包含概率 (PIP) 用于确定金属的意义.
主要成果:
- 对CRP水平的贡献最高 (PIP = 1.000),其次是 (0.6456) 和 (0.3528).
- 在金属暴露和CRP之间观察到非线性关系;呈现出U形的关联.
- 累积暴露效应表明CRP在50百分位以下增加,CRP在60百分位以上降低.
结论:
- 环境中的金属,特别是,与全身炎症有关.
- 公共卫生战略应解决累积金属暴露的影响.
- 先进的统计方法对于了解污染物对健康的影响至关重要.
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