暴露于per-和多醇基物质与心血管健康受损有关:一个横截面研究
Shuli Zong1, Lin Wang1, Sutong Wang1
1First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Frontiers in public health
|September 13, 2024
概括
暴露于per-和多醇基物质 (PFAS) 与美国成年人心血管疾病风险增加有关. 减少PFAS暴露可能会改善心血管健康并降低疾病负担.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 心血管科学 心血管科学
背景情况:
- 关于暴露于per-和多醇基物质 (PFAS) 和心血管疾病之间的联系存在争议.
- 评估血清PFAS水平与美国成年人心血管健康 (CVH) 之间的关联至关重要.
研究的目的:
- 为了研究血清PFAS度与美国成年人群中CVH受损之间的关联.
- 评估混合PFAS暴露对心血管健康结果的影响.
主要方法:
- 利用了2005-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 采用加权后勤回归,限制立方线,量子数g计算 (Qgcomp) 和加权量子数和 (WQS) 分析.
- 检查了单个PFAS和混合PFAS暴露与受损CVH之间的关联.
主要成果:
- 特定的PFAS,包括PFNA,PFOA和PFOS,与心血管功能受损的风险增加有关.
- 在PFOA,PFOS和受损的CVH之间观察到非线性关系.
- PFAS暴露和人口因素 (种族/种族,婚姻状况) 之间的相互作用对受损的CVH显著.
结论:
- PFNA,PFOA和PFOS暴露与美国成年人心血管健康受损的风险更高有关.
- 种族/种族和婚姻状况可能会改变PFAS对心血管硬化的影响.
- 尽量减少PFAS暴露是减少心血管疾病对公共卫生负担的潜在策略.
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