相关实验视频

Updated: Jun 13, 2025

In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines

In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines

Published on: April 18, 2025

作为预后不良的因素,PPIH增加了肝细胞癌中的细胞增殖和m6ARNA甲基化

Xiao-Xia Chi^1,2, Peng Ye³, Neng-Qi Cao⁴

¹Affiliated Cancer Hospital and Institute, Guangzhou Medical University Guangzhou 510095, Guangdong, China.

American journal of cancer research

|September 13, 2024

概括

乙-乙 cis-trans异构酶H (PPIH) 通过增加细胞增殖和改变瘤免疫微环境,促进肝癌 (LIHC) 的进展. 高PPIH表达是LIHC患者预后不良的因素.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物化学生物化学

背景情况:

RNA结合蛋白 (RBPs) 在肝肝细胞癌 (LIHC) 发病过程中至关重要.
乙烯-乙烯 cis-trans异构酶H (PPIH),一种具有乙烯异构酶和伴侣活性的RBP,在LIHC中起着不清楚的作用.

研究的目的:

阐明PPIH影响LIHC预后的机制.
调查PPIH在LIHC进展和瘤免疫微环境中的作用.

主要方法:

对LIHC组织和正常组织的生物信息学分析.
在体外实验中评估PPIH对细胞增殖,DNA复制和细胞周期基因的影响.
对m6ARNA甲基化水平和免疫细胞透的分析.

主要成果:

与正常组织相比,在LIHC组织中,PPIH表达显著上调.
高PPIH表达与更差的预后相关,并作为LIHC的独立预后因素.
PPIH增强m6ARNA甲基化,通过DNA复制和细胞周期调节促进细胞增殖,并增加免疫检查点蛋白表达.

结论:

PPIH通过增强m6ARNA甲基化,增加细胞增殖和调节瘤免疫微环境来促进LIHC进展.
PPIH是潜在的治疗标,也是LIHC的一个不良预后生物标志物.
需要进一步的研究,以充分理解PPIH在LIHC恶性瘤中的多方面的作用.

关键词:

在 PPIH 的情况下,PPIH 是 PPIH.这是一种RNA结合蛋白.细胞循环中的细胞循环.肝细胞癌是肝细胞癌.m6ARNA甲基化的过程瘤免疫的微环境

更多相关视频

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma

Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma

Published on: August 31, 2022

相关概念视频

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...

PI3K/mTOR/AKT Signaling Pathway

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...