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在局部晚期HNSCC中评估不同新辅助免疫疗法组合的疗效和安全性:系统性审查和元分析

Chang Liu¹, Mingzhu Li², Xiaojie Liu¹

¹Department of Burns and Plastic Surgery, Yantaishan Hospital, Yantai, China.

Frontiers in immunology

|September 13, 2024

概括

新辅助免疫疗法与化疗或放射疗法相结合,在头部和部癌症中改善了主要病理反应率. 需要进一步的研究来证实这些联合疗法的整体疗效.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
头部和部癌症研究研究

背景情况:

复发性/转移性头支状细胞癌 (HNSCC) 显示出免疫检查点抑制剂的前景.
临床试验正在探索新辅助免疫疗法对HNSCC的安全性和有效性.
本综述综合了针对HNSCC的联合新辅助免疫疗法方案的发现.

研究的目的:

系统地审查和分析针对HNSCC的新辅助免疫疗法的临床试验.
确定HNSCC最有效的新辅助免疫疗法方案.
评估不同治疗方案的疗效 (pCR,MPR,ORR) 和安全性 (TRAE,IRAE).

主要方法:

在PubMed,Embase,Cochrane图书馆和Web of Science的系统搜索,截至2024年7月1日.
分析了32项涉及1943名患者的研究.
评估病理反应率和与治疗相关的不良事件.

主要成果:

组合疗法 (免疫疗法 + 化疗/放射疗法) 显示出比单独免疫疗法更高的MPR率.
两组之间病理完整响应 (pCR) 率没有显著差异.
在组合治疗组中,除单独免疫疗法外,TRAEs和irAEs等级≥3的发病率相似.

结论:

新辅助免疫疗法,特别是与化疗或放射疗法相结合,可能有利于局部发达的HNSCC患者.
需要进一步的数据来确定这些结合的新辅助方法的有效性.
这些发现支持探索用于HNSCC治疗的联合新辅助免疫疗法.

关键词:

在HNSCC中,我们可以看到HNSCC.有效性有效性有效性.进行元分析分析.新辅助免疫疗法新辅助免疫疗法在安全方面,安全是安全的.

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