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Updated: Jun 26, 2026

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
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Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

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一个新型的二次ALK基因突变,该基因对第二代TKI具有抗性:一个案例报告和文献综述

Xiaqin Cheng1, Jia Liu2, Qiongxia Hu3

  • 1Thoracic Oncology Ward, Cancer Center, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Frontiers in oncology
|September 13, 2024
PubMed
概括

经过EML4-ALK融合的高级非小细胞肺癌 (NSCLC) 可能会由于二次突变而对ALK氨酸激酶抑制剂 (TKI) 产生耐药性. 一种新的E803Q突变对第二代TKIs产生了耐药性,这表明洛拉提尼布是潜在的治疗方法.

关键词:
在EML4-ALK基因融合过程中,非小细胞肺癌是非小细胞肺癌.案例报告案例报告第二代ALK-TKI的第二代.二次ALK突变的发生.

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