基因饮食与有氧运动可以诱导脂肪色:β-基酸盐的潜在作用
Sujin Kim1,2, Dong-Ho Park3,4, Sohee Moon1,2
1Department of Pharmacology, College of Medicine, Inha University, Incheon, Republic of Korea.
Frontiers in nutrition
|September 13, 2024
概括
β-基酸盐 (β-HB) 通过激活热生成和线粒体生物生成,促进白色脂肪组织 (WAT) 的色. 增加β-HB的代饮食和运动等干预措施可能会改善代谢健康.
科学领域:
- 代谢研究的研究.
- 脂肪组织生物学 脂肪组织生物学
- 线粒体功能 线粒体功能
背景情况:
- 已知代谢中间体,如β-hydroxybutyrate (β-HB),可以影响白色脂肪组织 (WAT) 的代谢.
- 然而,这些影响背后的精确分子机制,特别是关于脂肪色的精确分子机制,仍然不完全理解.
研究的目的:
- 调查β-基酸盐 (β-HB) 对白色脂肪组织 (WAT) 脂肪色程序的影响.
- 使用体外和体外模型阐明β-HB对WAT代谢影响的潜在分子机制.
主要方法:
- 在体外研究中,使用β-HB对3T3-L1脂肪细胞进行治疗,以评估对脂解,基因表达 (UCP1,PRDM16,FGF21,FNDC5) 和AMPK-SIRT1-PGC-1α通路的影响.
- 在体内研究中使用了雄性Sprague Dawley大鼠进行控制,运动 (EX),饮食 (KD) 和运动和饮食 (KE) 组合8周,随后对WAT组织学,血脂质,脂肪素和基因表达进行分析.
主要成果:
- 在体外,β-HB通过AMPK-SIRT1-PGC-1α通路降低了脂质积累,增强了脂解,并通过AMPK-SIRT1-PGC-1α通路调高了发热/棕色基因 (UCP1,PRDM16) 和基因 (FGF21,FNDC5).
- 在体内,KE组显示β-HB升高,体重降低和血脂. 结合KD和EX促进了WAT色,增加了PRDM16,UCP1,FGF21和FNDC5的表达.
结论:
- 通过性饮食和/或运动诱导β-甲酸 (β-HB) 促进WAT色.
- 这通过激活线粒体生物生成,脂解和热生成来发生,这表明对代谢健康的潜在益处.
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