在2型糖尿病患者中,加工红肉摄入量与心血管风险因素之间的关联:来自中国的横截面研究
Fan Zhang1, Yongfei Chai1,2, Jiajia Ren1
1School of Public Health, Bengbu Medical University, Bengbu, China.
Frontiers in nutrition
|September 13, 2024
概括
加工红肉 (PRM) 的消费与较差的血糖控制 (HbA1c) 和2型糖尿病 (T2DM) 的中国成年人血压升高有关. 限制PRM摄入量可能有助于预防心血管疾病.
科学领域:
- 内分泌学和新陈代谢学
- 心血管疾病研究研究
- 营养科学 营养科学
背景情况:
- 2型糖尿病 (T2DM) 是一个日益严重的全球健康问题,通常与心血管疾病 (CVD) 风险增加有关.
- 饮食因素,特别是加工红肉 (PRM) 消费,与代谢失调和心血管疾病有关.
- 了解PRM对T2DM患者心血管风险因素的具体影响,对于有效的管理和预防策略至关重要.
研究的目的:
- 调查加工红肉 (PRM) 消费与中国成年人被诊断患有2型糖尿病 (T2DM) 的各种心血管风险因素之间的关联.
- 分析剂量-反应关系,并确定影响这些关联的潜在效果修饰剂.
主要方法:
- 一项涉及316名T2DM患者的横截面研究在中国的Bengbu,利用饮食调查,物理测量和血液生物化学测试.
- 统计分析包括后勤回归来评估与PRM摄入相关的异常心血管风险因素水平的风险.
- 使用子组分析和受限立方支线图来探索混因素和剂量反应关系,包括非线性关联.
主要成果:
- 较高的PRM摄入量与较高的亚最佳HbA1c控制风险 (OR=2.620) 和异常的缩血压 (SBP) (OR=2.166) 有关.
- 在PRM摄入量和亚最佳HbA1c和SBP控制风险之间观察到非线性剂量反应关系.
- 在PRM摄入量和总胆固醇 (TC) 和LDL胆固醇 (LDL-C) 水平之间发现了一种非典型的反转U形关联.
结论:
- 尽管研究群体中PRM摄入量普遍较低,但发现与血糖控制较差和SBP升高有显著的关联.
- 观察到的非线性和反转的U形关系突出显示了T2DM中PRM消费和心血管风险标志物之间的复杂相互作用.
- 控制PRM摄入量可能是预防T2DM并发症和心血管疾病的宝贵策略.
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