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评估胆道样本中多药耐药细菌的频率和风险因素

Mehmet Yildiz¹, Merve Buyukkoruk¹, Seyma Arslan¹

¹Department of Infectious Disease and Clinical Microbiology, School of Medicine, Gazi University, Ankara, Türkiye.

Iranian journal of microbiology

|September 13, 2024

概括

胆道样本中的多药耐药 (MDR) 细菌在42.3%的患者中被发现. 胃肠道恶性瘤和先前使用抗生素是关键的危险因素,导致临床结果较差.

科学领域:

医学微生物学医学微生物学
传染性疾病传染性疾病
临床医学临床医学

背景情况:

胆道感染由于潜在的多药耐药 (MDR) 细菌参与而带来了重大挑战.
了解胆道样本中MDR细菌的流行率和风险因素对于有效的患者管理至关重要.

研究的目的:

为了确定胆道样本中MDR细菌的频率.
确定与胆道中MDR细菌感染相关的独立风险因素.
在这些感染中调查与MDR细菌阳性相关的临床结果.

主要方法:

一项回顾性研究分析了2018年5月至2023年5月期间202名成年患者的胆汁样本,其中有阳性培养.
使用单变量和多变量统计方法对MDR细菌的风险因素分析.
在MDR和非MDR组之间比较临床结果,包括抗生素治疗的适当性,持续时间,住院时间和住院死亡率.

主要成果:

总共分离了342种微生物,其中MDR细菌占病例的42.3%.
对MDR细菌的独立风险因素包括胃肠道恶性瘤 (OR: 1.96) 和以前的抗生素使用 (OR: 2.26).
MDR细菌的阳性与住院时间的增加 (24 vs. 15天,p=0.001) 和不适当的经验性抗生素治疗的趋势相关.

结论:

胆道样本中普遍存在MDR细菌,并与不良临床结果相关,包括长时间住院治疗.
胃肠道恶性瘤和最近的抗生素暴露是MDR细菌感染的重要危险因素.
查,预防和经验治疗的临床策略应考虑胆道感染患者的这些危险因素.

关键词:

抗生素预防抗生素预防抗微生物药物管理管理胆道通道中的胆道通道.结肠直肠外科手术是什么意思药物耐药性药物耐药性药物耐药性胃肠道的新生病.微生物微生物的存在

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