对于妊娠年龄而言小而没有赶上成长速度的儿童出生时的大脑形态变化
Tomozumi Takatani1, Tadashi Shiohama1, Rieko Takatani2
1Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Frontiers in neuroscience
|September 13, 2024
概括
对于妊娠年龄 (SGA) 较小的婴儿出生时,如果婴儿没有达到追赶增长,则会显示左侧胰岛体积和厚度减少. 这种大脑形态差异可能会影响智力和心理发展.
科学领域:
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
- 发展生物学 发展生物学
背景情况:
- 大多数为妊娠年龄 (SGA) 生小的婴儿实现追赶增长,但有些人没有.
- 无法实现追赶增长与健康风险有关,包括神经心理问题.
- 有限的数据存在于SGA婴儿的脑形态,这些婴儿没有达到追赶成长.
研究的目的:
- 为了研究出生在没有追赶成长的SGA儿童的大脑结构特征.
- 确定受SGA婴儿缺乏追赶成长影响的特定大脑区域.
主要方法:
- 基于voxel和表面的形态测量分析是在T1加权的大脑MRI扫描上进行的.
- 没有追赶增长的8名SGA婴儿与16名具有特异性矮身 (ISS) 个体进行了比较.
- 所有参与者都排除了生长激素 (GH) 缺乏症;统计分析包括t测试和本雅米尼-霍赫伯格校正.
主要成果:
- 形态测量分析显示,与ISS组相比,SGA婴儿的左侧岛屿厚度和体积下降,没有追赶成长.
- 在缺乏追赶成长的SGA婴儿中观察到明显的形态大脑差异.
结论:
- 该研究确定了在没有追赶成长的SGA婴儿中特定的大脑形态差异.
- 这些发现可能有助于更好地理解SGA与没有追赶成长和智力/心理结果之间的关联.
相关概念视频
Nature and Nurture
20.4K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.4K
Biological Influences on Intelligence
83
Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter...
83


