相关实验视频

Updated: Jun 13, 2025

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

HNRNPA2B1对人类癌症的潜在影响预后和免疫微环境

Tao Huang¹, Gang Zhu¹, Fan Chen¹

¹Department of Neurosurgery Tangdu Hospital Fourth Military Medical University, Xi'an, China.

Journal of immunology research

|September 13, 2024

概括

RNA结合蛋白HNRNPA2B1与较差的癌症预后有关,并影响瘤微环境 (TME). 这项泛癌研究揭示了其作为预后生物标志物和免疫调节标的潜力.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

异质核核核糖核蛋白A2B1 (HNRNPA2B1) 涉及到mRNA拼接和翻译等细胞过程,已知在瘤发育中的作用.
尚未对HNRNPA2B1进行全面的全癌症分析,特别是关于其在瘤微环境 (TME) 中的作用.

研究的目的:

进行HNRNPA2B1表达及其临床意义的泛癌调查.
探索HNRNPA2B1与瘤特征,免疫格局和患者预后的关联.

主要方法:

在TCGA,TARGET,GTEx和人类蛋白质图谱数据集上利用了生物信息学方法.
分析了HNRNPA2B1表达与预后的相关性,瘤突变负担 (TMB),微卫星不稳定性 (MSI) 和免疫细胞透.
使用免疫组织化学验证的结果.

主要成果:

在许多癌症类型中,HNRNPA2B1具有差异性表达,并预测不良的临床阶段和存活率.
表达水平与TMB,MSI,瘤干和化疗反应相关.
HNRNPA2B1显著影响TME,影响免疫细胞透 (巨细胞,树突细胞,NK,T细胞) 和与免疫相关的基因.

结论:

HNRNPA2B1作为各种癌症的潜在预后生物标志物.
HNRNPA2B1在TME中表现出显著的免疫调节功能,这表明它在新型免疫疗法中的作用.

更多相关视频

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

Predictive Immune Modeling of Solid Tumors

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

The Nucleolus

The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...