在视频辅助胸腔镜手术中进行手术内氧化吸入,以预防慢性术后疼痛:一项前性观察队列研究
Yuchen Yuan1, Le Zhang1, Yuelun Zhang2
1Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Journal of thoracic disease
|September 13, 2024
概括
在手术期间吸入氧化 (N2O) 可能减少中国患者经历视频辅助胸腔镜手术 (VATS) 的慢性术后疼痛 (CPSP). 这一发现表明N2O可能是预防VATS后长期疼痛的保护因素.
科学领域:
- 麻醉学 麻醉学
- 疼痛管理 疼痛管理
- 胸部外科手术 胸部外科手术
背景情况:
- 慢性术后疼痛 (CPSP) 显著阻碍了手术后的康复.
- 氧化 (N2O) 已证明具有长期止痛的潜力.
- 以前的研究表明,N2O可能有助于预防中国人群中的CPSP.
研究的目的:
- 调查在手术期间吸入N2O是否起到对CPSP的保护作用.
- 评估N2O在视频辅助胸腔镜手术 (VATS) 后预防慢性疼痛的疗效.
主要方法:
- 一项包括833名在北京联合医学院医院接受VATS的患者的队列研究.
- 患者被分为在手术期间吸入N2O和没有吸入N2O的组.
- 评估了术后6个月的疼痛结果,并使用多变量逻辑回归分析数据.
主要成果:
- 46.5%的患者在6个月后出现了CPSP.
- 吸入N2O与较低的CPSP发病率相关 (40.0%与52.4%相比).
- 经调整后的分析证实,吸入N2O显著降低了患CPSP的几率 (OR = 0.654;P=0.007).
结论:
- 在VATS期间吸入N2O与发展CPSP的可能性降低有关.
- 在胸腔镜手术后,N2O可以作为预防慢性疼痛的有益剂.
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