热饮品温度偏好对食道癌症风险的因果关系:孟德尔的随机化研究
Mengyuan Zhu1, Min Wei1, Shan Huang1
1Department of Oncology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Journal of thoracic disease
|September 13, 2024
概括
这项门德尔随机化研究发现,在欧洲或东亚人群中,热饮品温度偏好与食道癌症 (EC) 风险之间没有因果关系. 目前的证据不支持减少热饮的摄入量以防止EC.
科学领域:
- 流行病学 流行病学
- 遗传学 遗传学 是一个
- 癌症研究 癌症研究
背景情况:
- 以前的研究表明,热饮消费与食道癌症 (EC) 风险之间存在联系.
- 饮料温度和EC之间的确定的因果关系尚未确定.
- 本研究调查了热饮品温度偏好对EC风险的因果关系.
研究的目的:
- 评估热饮品温度偏好对食道癌 (EC) 风险的因果关系,使用孟德尔随机化 (MR).
- 提供关于热饮饮料消费习惯与EC发展之间的关联的遗传证据.
主要方法:
- 使用双样本的门德尔随机化 (MR) 分析与全基因组关联研究 (GWAS) 数据.
- 包括来自欧洲 (457,873名参与者) 和东亚 (2,617名参与者) 的人口的大队伍.
- 采用逆方差加权 (IVW) 作为主要方法,并进行灵敏度分析 (MR Egger,加权中位数) 以确保稳定性.
主要成果:
- 在欧洲人群中没有观察到热饮品温度偏好对EC风险的显著因果关系 (ORIVW=1.00,P=0.54;ORIVW=0.35,P=0.12).
- 同样,在东亚人群中也没有发现显著的因果关系 (ORIVW=1.09,P=0.59;ORIVW=0.11,P=0.49).
- 分析证实了在两个族群中一致的零发现.
结论:
- MR 分析表明热饮品温度偏好与食道癌症风险之间没有因果关系.
- 目前的遗传证据不支持这样的假设,即减少热饮的摄入量可以防止EC.
- 可能需要进一步的研究来充分阐明饮食和食道癌症之间的复杂关系.
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