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患有病理性T1N0阶段食道状细胞癌,经过食道切除术的患者的预后预测模型

Qing Liu¹, Yue Li², Zhong-Feng Yan²

¹Integrated Care Management Center, West China Hospital, Sichuan University, Chengdu, China.

Journal of thoracic disease

|September 13, 2024

概括

这项研究开发了一种名图,用于预测早期食道状细胞癌 (ESCC) 患者没有淋巴结转移 (LNM) 的生存率. 该模型确定了手术方法,T1次阶段和CEA水平作为改善患者结果的关键预后因素.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
癌症预后癌症预后

背景情况:

早期食道状细胞癌 (ESCC) 缺乏对没有淋巴结转移 (LNM) 的患者可靠的预后模型.
准确的预后对于指导T1N0ESCC治疗决策至关重要.
需要预测工具来分层风险,并为管理策略提供信息.

研究的目的:

开发和验证T1N0ESCC患者整体存活期 (OS) 的预测性名谱.
为了确定这个患者队列中生存的独立预后因素.
提供个性化风险评估和生存预测的工具.

主要方法:

来自三个研究所的275名T1N0ESCC患者 (2014-2021) 的回顾性审查.
使用考克斯的比例危险模型和名ogram开发的预测因素评估.
通过Kaplan-Meier方法和日志等级测试进行生存分析;执行外部验证.

主要成果:

多变量分析确定了手术方法,T1次阶段和癌胚抗原 (CEA) 水平作为独立的预后因素.
诺米图表表现出良好的预测性能 (AUC为1年,3年,5年的生存期:0.783,0.711,0.612).
基于名录的风险分层识别出高风险和低风险组,具有显著不同的OS (P<0.001).

结论:

左侧手术方法,T1b亚阶段和CEA升高与T1N0ESCC的预后较差有关.
开发的诺米图有效预测T1N0ESCC患者的个体生存结果.
该工具有助于个性化风险评估和临床决策,用于早期ESCC.

关键词:

消化管状细胞癌 (ESCC) 是一种 T1阶段T1阶段淋巴结转移 (LNM) 的发生.预后因素预后因素

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