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Updated: Jun 13, 2025

Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases
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一种经过工程设计的,与ubiquitin结合的卷状卷状

Pernille Vosbein1, Paula Paredes Vergara2, Danny T Huang2,3

  • 1School of Chemistry, University of Glasgow Glasgow G12 8QQ UK Drew.Thomson@glasgow.ac.uk.

Chemical science
|September 13, 2024
PubMed
概括

研究人员设计了一种稳定的卷曲-卷曲基架,呈现出基相互作用基因 (UIM) 残留物. 这种新型的CC-UIM与UIM单独相比,显示了与ubiquitin (Ub) 的增强结合,为蛋白质结合剂设计提供了新的策略.

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